Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.6.1.2 extracted from

  • Hoek, J.B.; Rydström, J.
    Physiological roles of nicotinamide nucleotide transhydrogenase (1988), Biochem. J., 254, 1-10.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
NAD+ product inhibition of forward reaction i.e. reduction of NADP+ by NADH Mammalia
NADH product inhibition of reverse reaction i.e. reduction of NAD+ by NADPH Mammalia
NADP+ product inhibition of reverse reaction i.e. reduction of NAD+ by NADPH Mammalia
NADPH product inhibition of forward reaction i.e. reduction of NADP+ by NADH Mammalia

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane
-
Mammalia 31966
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + NADP+ Mammalia forward reaction NADPH + NAD+
-
r
NADH + NADP+ Mammalia physiological role NADPH + NAD+
-
r

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + NADP+ the reaction is coupled to a transmembrane proton translocation from cytosol to mitochondria Mammalia NAD+ + NADPH
-
r
NADH + NADP+ forward reaction Mammalia NADPH + NAD+
-
r
NADH + NADP+ physiological role Mammalia NADPH + NAD+
-
r

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mammalia
NADH
-
Mammalia
NADP+
-
Mammalia
NADPH
-
Mammalia