Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | electrochemical gradient forces reaction | Rhodospirillum rubrum | |
additional information | electrochemical gradient forces reaction | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
dI and native and E155W mutant of dIII expressed in Escherichia coli | Rhodospirillum rubrum |
dIII domain expressed in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
dI2dIII complex in its thio-NAD+/NADP+ form | Rhodospirillum rubrum |
dIII domain in its thio-NADP+ form | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E155W | dIII domain, displays similar catalytic properties as wild type, introduced tryptophan fluorescence is sensitive to the redox state of the bound nucleotide | Rhodospirillum rubrum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Rhodospirillum rubrum | 16020 | - |
mitochondrial membrane | - |
Homo sapiens | 31966 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADH + NADP+ | Rhodospirillum rubrum | links hydride transfer between NAD(H) and NADP(H) to the outside-in translocation of protons across membrane | NAD+ + NADPH | - |
r | |
NADH + NADP+ | Homo sapiens | links hydride transfer between NAD(H) and NADP(H) to the outside-in translocation of protons across membrane | NAD+ + NADPH | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13423 | - |
- |
Rhodospirillum rubrum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant protein | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADH + NADP+ | - |
Rhodospirillum rubrum | NAD+ + NADPH | - |
r | |
NADH + NADP+ | - |
Homo sapiens | NAD+ + NADPH | - |
r | |
NADH + NADP+ | links hydride transfer between NAD(H) and NADP(H) to the outside-in translocation of protons across membrane | Rhodospirillum rubrum | NAD+ + NADPH | - |
r | |
NADH + NADP+ | links hydride transfer between NAD(H) and NADP(H) to the outside-in translocation of protons across membrane | Homo sapiens | NAD+ + NADPH | - |
r | |
NADH + oxidized 3-acetylpyridine adenine dinucleotide | - |
Rhodospirillum rubrum | NAD+ + reduced 3-acetylpyridine adenine dinucleotide | - |
? | |
NADH + thio-NADP+ | good substrate | Rhodospirillum rubrum | NAD+ + thio-NADPH | - |
r | |
NADPH + oxidized 3-acetylpyridine adenine dinucleotide | - |
Rhodospirillum rubrum | NADP+ + reduced 3-acetylpyridine adenine dinucleotide | - |
? | |
thio-NADH + NADP+ | poor substrate | Rhodospirillum rubrum | thio-NAD+ + NADPH | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | two monomers with dI, dII, and dIII domain structure | Rhodospirillum rubrum |
dimer | two monomers with dI, dII, and dIII domain structure | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD(P)+ | - |
Rhodospirillum rubrum | |
NAD(P)+ | - |
Homo sapiens | |
NAD(P)H | - |
Rhodospirillum rubrum | |
NAD(P)H | - |
Homo sapiens |