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Literature summary for 1.6.1.2 extracted from

  • Lopert, P.; Patel, M.
    Nicotinamide nucleotide transhydrogenase (Nnt) links the substrate requirement in brain mitochondria for hydrogen peroxide removal to the thioredoxin/peroxiredoxin (Trx/Prx) system (2014), J. Biol. Chem., 289, 15611-15620 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADPH + NAD+ Rattus norvegicus
-
NADP+ + NADH
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
N-27 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + 3-acetylpyridine adenine dinucleotide
-
Rattus norvegicus NADP+ + reduced 3-acetylpyridine adenine dinucleotide
-
?
NADPH + NAD+
-
Rattus norvegicus NADP+ + NADH
-
?

Synonyms

Synonyms Comment Organism
nicotinamide nucleotide transhydrogenase
-
Rattus norvegicus
NNT
-
Rattus norvegicus

General Information

General Information Comment Organism
malfunction enzyme inhibition decreases NADPH levels, decreases thioredoxin and thioredoxin reductase activity, and increases toxicity to oxidative stress Rattus norvegicus
physiological function the enzyme links mitochondrial respiration and antioxidant activity in brain mitochondria Rattus norvegicus