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Literature summary for 1.6.1.3 extracted from

  • Mercer, N.A.; McKelvey, J.R.; Fioravanti, C.F.
    Hymenolepis diminuta: catalysis of transmembrane proton translocation by mitochondrial NADPH->NAD transhydrogenase (1999), Exp. Parasitol., 91, 52-58.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
carbonyl cyanide 3-chlorophenylhydrazone
-
Hymenolepis diminuta
carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
-
Hymenolepis diminuta
niclosamide
-
Hymenolepis diminuta

Inhibitors

Inhibitors Comment Organism Structure
1,3-dicyclohexyl-1,3-diazapropa-1,2-diene
-
Hymenolepis diminuta

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane
-
Hymenolepis diminuta 5743
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADPH + NAD+ Hymenolepis diminuta
-
NADP+ + NADH
-
r

Organism

Organism UniProt Comment Textmining
Hymenolepis diminuta
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + NAD+
-
Hymenolepis diminuta NADP+ + NADH
-
r

Synonyms

Synonyms Comment Organism
mitochondrial NADPH->NAD transhydrogenase
-
Hymenolepis diminuta

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Hymenolepis diminuta

General Information

General Information Comment Organism
physiological function the enzyme of adult Hymenolepis diminuta physiologically couples matrix-localized, NADP-specific malic enzyme with NADH-dependent anaerobic electron transport. The enzyme acts in the translocation of protons from the matrix to the intermembrane space mitochondrial compartment Hymenolepis diminuta