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Literature summary for 1.6.2.2 extracted from

  • Celik, H.; Ko?ar, M.
    Inhibitory effects of dietary flavonoids on purified hepatic NADH-cytochrome b5 reductase: structure-activity relationships (2012), Chem. Biol. Interact., 197, 103-109.
    View publication on PubMed

Application

Application Comment Organism
drug development flavonoids, regarding b5 reductase inhibition, indicate a potential for significant flavonoid–drug and/or flavonoid–xenobiotic interactions which may have important therapeutic and toxicological outcomes for certain drugs and/or xenobiotics. Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
(+)-catechin
-
Bos taurus
(-)-epicatechin
-
Bos taurus
apigenin
-
Bos taurus
luteolin
-
Bos taurus
luteolin-7-O-glucoside
-
Bos taurus
additional information inhibitory potencies of flavonoids on the enzyme, structure-activity relationship, overview. No inhibition by naringenin, naringin, and chrysin. Flavonoids containing two hydroxyl groups in ring B and a carbonyl group at C-4 in combination with a double bond between C-2 and C-3 produced a much stronger inhibition, whereas substitution of a hydroxyl group at C-3 is associated with a less inhibitory effect Bos taurus
morin
-
Bos taurus
myricetin
-
Bos taurus
quercetin
-
Bos taurus
quercitrin
-
Bos taurus
rutin
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Bos taurus
-
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from liver microsomes by anion exchange chromatography and affinity chromatography Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ferricyanide + NADH
-
Bos taurus 2 ferrocyanide + NAD+ + H+
-
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Synonyms

Synonyms Comment Organism
cytochrome b5 reductase
-
Bos taurus
NADH-cytochrome b5 reductase
-
Bos taurus
NADH-ferricyanide reductase
-
Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at room temperature Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADH
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00011
-
pH 7.5, 22°C Bos taurus luteolin
0.00081
-
pH 7.5, 22°C Bos taurus morin
0.0011
-
pH 7.5, 22°C Bos taurus quercetin
0.0012
-
pH 7.5, 22°C Bos taurus quercitrin
0.0015
-
pH 7.5, 22°C Bos taurus myricetin
0.0024
-
pH 7.5, 22°C Bos taurus luteolin-7-O-glucoside
0.0032
-
pH 7.5, 22°C Bos taurus (-)-epicatechin
0.0045
-
pH 7.5, 22°C Bos taurus (+)-catechin
0.036
-
pH 7.5, 22°C Bos taurus apigenin
0.057
-
pH 7.5, 22°C Bos taurus rutin

General Information

General Information Comment Organism
additional information structure-activity relationship, overview Bos taurus