Literature summary for 1.6.2.4 extracted from

Gu, J.; Cui, H.; Behr, M.; Zhang, L.; Zhang, Q.Y.; Yang, W.; Hinson, J.A.; Ding, X.
In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa (2005), Mol. Pharmacol., 67, 623-630.

Search for more literature for 1.6.2.4

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Mus musculus	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2 ferricytochrome P450 + NADPH	Mus musculus	involved in drug metabolism, NADPH-cytochrome P450 deletion mouse is resistant to acetaminophen concentrations at doses toxic for normal mice	2 ferrocytochrome P450 + NADP+ + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	normal mouse and NADPH-cytochrome P450 deletion mutant	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 ferricytochrome c + NADPH	-	Mus musculus	2 ferrocytochrome c + NADP+ + H+	-	?
2 ferricytochrome P450 + NADPH	involved in drug metabolism, NADPH-cytochrome P450 deletion mouse is resistant to acetaminophen concentrations at doses toxic for normal mice	Mus musculus	2 ferrocytochrome P450 + NADP+ + H+	-	?

Synonyms

Synonyms	Comment	Organism
NADPH-cytochrome P450 reductase	-	Mus musculus
NADPH-ferrihemoprotein reductase	-	Mus musculus
NADPH:ferrihemoprotein oxidoreductase	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
FAD	together with FMN	Mus musculus
FMN	together with FAD	Mus musculus
NADPH	-	Mus musculus

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Release 2023.1 (January 2023)