Literature summary for 1.6.2.4 extracted from

Barnaba, C.; Martinez, M.J.; Taylor, E.; Barden, A.O.; Brozik, J.A.
Single-protein tracking reveals that NADPH mediates the insertion of cytochrome P450 reductase into a biomimetic of the endoplasmic reticulum (2017), J. Am. Chem. Soc., 139, 5420-5430 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	CPR can exist as a peripheral membrane protein in the absence of NADPH and will transition to an integral membrane protein in the presence of stoichiometric amounts of NADPH or greater	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
CPR	-	Homo sapiens
cytochrome P450 reductase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	NADPH mediates the interaction of CPR with a bilayer that mimics the endoplasmic reticulum. Without NADPH, CPR behaves as a peripheral protein. The introduction of NADPH transforms CPR to an integral membrane protein	Homo sapiens

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Release 2023.1 (January 2023)