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Literature summary for 1.6.3.1 extracted from
- Mechanisms for the activation/electron transfer of neutrophil NADPH-oxidase complex and molecular pathology of chronic granulomatous disease (1994), Ann. Hematol., 68, 267-277.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Protein kinase C | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Cavia porcellus | 16020 | - |
| membrane | - |
Sus scrofa | 16020 | - |
| membrane | - |
Bos taurus | 16020 | - |
| membrane | subunit gp91-phox of cytochrome b558 of the multicomponent complex is an integral membrane protein with several membrane-spanning regions | Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADPH + O2 | Cavia porcellus | - |
NADP+ + O2- | - |
? |  |
| NADPH + O2 | Sus scrofa | - |
NADP+ + O2- | - |
? | |
| NADPH + O2 | Bos taurus | - |
NADP+ + O2- | - |
? | |
| NADPH + O2 | Homo sapiens | part of defense mechanism against a wide variety of bacteria | NADP+ + O2- | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cavia porcellus | - |
- |
- |
| Homo sapiens | - |
multicomponent NADPH-oxidase consisting of a heterodimeric flavocytochrome b558, localized in the membrane and at least two cytosolic components p47-phox and p67-phox, enzyme plays a role in chronic granulomatous diseases, enzyme system is activated upon exposure to the appropriate stimuli leading to assembly in the plasma membrane of membrane-bound and cytosolic components | - |
| Sus scrofa | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | cytochrome b558 subunit gp91-phox of the multicomponent complex is heavily glycosylated | Homo sapiens |
| side-chain modification | phosphorylation of cytosolic component p47-phox | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| cytochrome b558 and cytosolic components p47-phox and p67-phox | Homo sapiens |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| NAD(P)H + H+ + O2 = NAD(P)+ + H2O2 | model of electron transport from NADPH to the terminal electron acceptor O2 | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neutrophil | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADPH + O2 | - |
Cavia porcellus | NADP+ + O2- | - |
? | |
| NADPH + O2 | - |
Homo sapiens | NADP+ + O2- | - |
? | |
| NADPH + O2 | - |
Sus scrofa | NADP+ + O2- | - |
? | |
| NADPH + O2 | - |
Bos taurus | NADP+ + O2- | - |
? | |
| NADPH + O2 | part of defense mechanism against a wide variety of bacteria | Homo sapiens | NADP+ + O2- | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 47000-48000, p47-phox, cytosolic component of the multicomponent complex, SDS-PAGE | Homo sapiens |
| ? | x * 65000-67000, p67-phox, cytosolic component of the multicomponent complex, SDS-PAGE | Homo sapiens |
| dimer | 1 * 22000-23000 + 1 * 76000-91000, subunits of the membrane component of the enzyme complex, cytochrome b558, SDS-PAGE | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Cavia porcellus | |
| FAD | - |
Sus scrofa | |
| FAD | - |
Bos taurus | |
| FAD | cytochrome b558 of the multienzyme complex may contain FAD and heme | Homo sapiens | |
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