Literature summary for 1.6.3.1 extracted from

Ferreira, A.C.F.; Cardoso, L.d.C.; Rosenthal, D.; Pires de Carvalho, D.
Thyroid Ca2+/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole (2003), Eur. J. Biochem., 270, 2363-2368.

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Inhibitors

Inhibitors	Comment	Organism	Structure
methimazol	partial	Homo sapiens
propylthiouracil	partial	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	regulates enzyme activity	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD(P)H + H+ + O2	Homo sapiens	production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis	NAD(P)+ + H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
thyroid gland	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD(P)H + H+ + O2	-	Homo sapiens	NAD(P)+ + H2O2	-	?
NAD(P)H + H+ + O2	production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis	Homo sapiens	NAD(P)+ + H2O2	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.026	-	propylthiouracil	-	Homo sapiens
0.031	-	methimazol	-	Homo sapiens

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Release 2023.1 (January 2023)