Literature summary for 1.6.3.1 extracted from

Park, H.S.; Park, D.; Bae, Y.S.
Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1 (2006), Biochem. Biophys. Res. Commun., 339, 985-990.

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Inhibitors

Inhibitors	Comment	Organism	Structure
betaPix	guanine nucleotide exchange factor, overexpression of the central PH domain of betaPix results in inhibition of superoxide anion generation in response to EGF	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	formation of a complex consisting of enzyme, guanine exchange factor for Rac, betaPix, and enzyme organizer NoxO1 is a critical step in EGF-induced generation of reactive oxygen species	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform Nox1	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	formation of a complex consisting of enzyme, guanine exchange factor for Rac, betaPix, and enzyme organizer NoxO1 is a critical step in EGF-induced generation of reactive oxygen species	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
More	guanine nucleotide exchange factor betaPix interacts with enzyme with the PH domain of betaPix binding to the FAD-binding region of enzyme. Additionally, NADPH oxidase organizer 1, NoxO1, interacts with enzyme	Homo sapiens

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Release 2023.1 (January 2023)