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BRENDA support

Literature summary for 1.6.3.1 extracted from

  • Chen, P.; Guo, A.M.; Edwards, P.A.; Trick, G.; Scicli, A.G.
    Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis (2007), Am. J. Physiol. Regul. Integr. Comp. Physiol., 293, R1619-R1629.
    View publication on PubMed
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Application

Application Comment Organism
medicine intravitreal injections of angiotensin II can result in retinal leukostasis, which appears to be mediated via increasing superoxide generation by NAD(P)H oxidase, and by vasular endothelial growth factor. The activity of NAD(P)H oxidase is required for leukostasis to occur in the diabetic retina Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
apocynin
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
retina
-
 Rattus norvegicus
-