Literature summary for 1.6.3.1 extracted from

Li, B.; Guo, Y.S.; Sun, M.M.; Dong, H.; Wu, S.Y.; Wu, D.X.; Li, C.Y.
The NADPH oxidase is involved in lipopolysaccharide-mediated motor neuron injury (2008), Brain Res., 1226, 199-208.

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Activating Compound

Activating Compound	Comment	Organism	Structure
lipopolysaccharide	exposure tolipopolysaccharide leads to the demise of motor neurons in a dose- and time-dependent manner, whereas interneurons are impaired relatively mildly. NADPH oxidase is activated upon lipopolysaccharide challenge, and inhibitor apocynin prevents inflammation-mediated toxicity to motor neurons	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
apocynin	prevents inflammation-mediated toxicity to motor neurons induced by lipopolysaccharide	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
spinal cord	lumbal spinal cord slice	Rattus norvegicus	-

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Release 2023.1 (January 2023)