Literature summary for 1.6.3.1 extracted from

Sanchez, G.; Escobar, M.; Pedrozo, Z.; Macho, P.; Domenech, R.; Haertel, S.; Hidalgo, C.; Donoso, P.
Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: possible role in cardioprotection (2008), Cardiovasc. Res., 77, 380-386.

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Application

Application	Comment	Organism
medicine	in sarcoplasmic reticulum vesicles isolated after exercise and tachycardia, increase in NAD(P)H oxidase activity, ryanodine receptor-2 S-glutathionylation, and calcium release rates. Apocynin prevents the increase in ryanodine receptor-2 S-glutathionylation, reduced calcium release activity, and completely prevents the protective effects of exercise and tachycardia on infarct size	Canis lupus familiaris

Inhibitors

Inhibitors	Comment	Organism	Structure
apocynin	in sarcoplasmic reticulum vesicles isolated after exercise and tachycardia, apocynin prevents the increase in ryanodine receptor-2 S-glutathionylation, reduced calcium release activity, and completely prevents the protective effects of exercise and tachycardia on infarct size	Canis lupus familiaris

Organism

Organism	UniProt	Comment	Textmining
Canis lupus familiaris	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ventriculus	in sarcoplasmic reticulum vesicles isolated after exercise and tachycardia, increase in NAD(P)H oxidase activity, ryanodine receptor-2 S-glutathionylation, and calcium release rates. Cardiac muscle displays significant colocalization of NADPH oxidase and ryanodine receptor-2	Canis lupus familiaris	-

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Release 2023.1 (January 2023)