Literature summary for 1.6.3.1 extracted from

Szoecs, K.; Lassegue, B.; Wenzel, P.; Wendt, M.; Daiber, A.; Oelze, M.; Meinertz, T.; Muenzel, T.; Baldus, S.
Increased superoxide production in nitrate tolerance is associated with NAD(P)H oxidase and aldehyde dehydrogenase 2 downregulation (2007), J. Mol. Cell. Cardiol., 42, 1111-1118.

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Activating Compound

Activating Compound	Comment	Organism	Structure
nitroglycerin	in vascular smooth muscle cells exposed to nitroglycerin for 6-24 h, NAD(P)H oxidase activity is increased, in spite of isoform nox1 downregulation	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
nitroglycerin	in rats treated with nitroglycerin for three days, superoxide production is increased in all aortic layers, while expression of isoforms nox1, nox2 and nox4 is significantly decreased. In vascular smooth muscle cells exposed to nitroglycerin for 6-24 h, NAD(P)H oxidase activity is increased, in spite of nox1 downregulation	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aortic smooth muscle cell	commercial preparation	Rattus norvegicus	-

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Release 2023.1 (January 2023)