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Literature summary for 1.6.3.1 extracted from

  • Zhang, D.; Hu, X.; Wei, S.; Liu, J.; Gao, H.; Qian, L.; Wilson, B.; Liu, G.; Hong, J.
    Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity (2008), J. Neuroinflammation, 5, 21.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine N-[2-(4-hydroxy-phenyl)-ethyl]-2-(2, 5-dimethoxy-phenyl)-3-(3-methoxy-4-hydroxy-phenyl)-acrylamide i.e. FLZ, squamosamide derivative. FLZ inhibits the translocation of the cytosolic subunit p47phox to the membrane and thus inhibits the activation of NAD(P)H oxidase. In vivo, FLZ significantly protects against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced dopaminergic neuronal loss Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
N-[2-(4-hydroxy-phenyl)-ethyl]-2-(2, 5-dimethoxy-phenyl)-3-(3-methoxy-4-hydroxy-phenyl)-acrylamide i.e. FLZ, squamosamide derivative. FLZ inhibits the translocation of the cytosolic subunit p47phox to the membrane and thus inhibits the activation of NAD(P)H oxidase. In vivo, FLZ significantly protects against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced dopaminergic neuronal loss Mus musculus
N-[2-(4-hydroxy-phenyl)-ethyl]-2-(2, 5-dimethoxy-phenyl)-3-(3-methoxy-4-hydroxy-phenyl)-acrylamide i.e. FLZ, squamosamide derivative, mediates anti-inflammatory and neuroprotective effects in both lipopolysaccharide-and 1-methyl-4-phenylpyridinium-mediated models of Parkinson's disease. FLZ inhibits the translocation of the cytosolic subunit p47phox to the membrane and thus inhibits the activation of NAD(P)H oxidase Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
glial cell mesencephalic neuron-glial culture and reconstituted culture Rattus norvegicus
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glial cell primary mesencephalic neuron-glial culture Mus musculus
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