Literature summary for 1.6.3.1 extracted from

Bhandarkar, S.S.; Jaconi, M.; Fried, L.E.; Bonner, M.Y.; Lefkove, B.; Govindarajan, B.; Perry, B.N.; Parhar, R.; Mackelfresh, J.; Sohn, A.; Stouffs, M.; Knaus, U.; Yancopoulos, G.; Reiss, Y.; Benest, A.V.; Augustin, H.G.; Arbiser, J.L.
Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice (2009), J. Clin. Invest., 119, 2359-2365.

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Inhibitors

Inhibitors	Comment	Organism	Structure
fulvene-5	potent inhibitor of NADPH oxidase 4	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain endothelial cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
NADPH oxidase 4	-	Mus musculus
Nox4	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	Nox4 is downregulated in angiopoietin 2 heterozygous cells	down

General Information

General Information	Comment	Organism
malfunction	lentiviral silencing of Nox4 in an Ang2-sufficient bEnd cell line decreases Ang2 mRNA levels and greatly impairs hemangioma growth in vivo	Mus musculus
physiological function	Nox4 is a critical regulator of hemangioma growth	Mus musculus

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Release 2023.1 (January 2023)