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Literature summary for 1.6.3.1 extracted from

  • Zia, M.T.; Csiszar, A.; Labinskyy, N.; Hu, F.; Vinukonda, G.; LaGamma, E.F.; Ungvari, Z.; Ballabh, P.
    Oxidative-nitrosative stress in a rabbit pup model of germinal matrix hemorrhage: role of NAD(P)H oxidase (2009), Stroke, 40, 2191-2198.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.6.3.1

Inhibitors

Inhibitors Comment Organism Structure
apocynin
-
 Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
forebrain
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + O2
-
 Oryctolagus cuniculus NADP+ + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
NADPH oxidase
-
 Oryctolagus cuniculus

Expression

Organism Comment Expression
Oryctolagus cuniculus NADPH oxidase activity is significantly increased in both the periventricular region and cortex of pups with intraventricular hemorrhage than glycerol- and saline-treated controls at 6h age, and remains substantially elevated at 24h postnatal age up

General Information

General Information Comment Organism
malfunction NAD(P)H oxidase inhibition by apocynin might suppress reactive oxygen species production and confer neuroprotection in premature infants with intraventricular hemorrhage Oryctolagus cuniculus
physiological function germinal matrix hemorrhage-intraventricular hemorrhage, by induction of NAD(P)H oxidases, may cause oxidative/nitrosative stress contributing to brain injuries. Activation of NAD(P)H oxidase is the predominant mechanism of free-radical generation in pups with intraventricular hemorrhage Oryctolagus cuniculus