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Literature summary for 1.6.3.1 extracted from

  • van der Hoeven, R.; Cruz, M.R.; Chavez, V.; Garsin, D.A.
    Localization of the dual oxidase BLI-3 and characterization of its NADPH oxidase domain during infection of Caenorhabditis elegans (2015), PLoS ONE, 10, e0124091 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.6.3.1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + H+ + O2 Caenorhabditis elegans
-
 NAD+ + H2O2
-
 ?
NADPH + H+ + O2 Caenorhabditis elegans
-
 NADP+ + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hypodermis
-
 Caenorhabditis elegans
-
intestine
-
 Caenorhabditis elegans
-
pharynx
-
 Caenorhabditis elegans
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + H+ + O2
-
 Caenorhabditis elegans NAD+ + H2O2
-
 ?
NADPH + H+ + O2
-
 Caenorhabditis elegans NADP+ + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
BLI-3 the dual oxidase enzyme has a NADPH oxidase domain Caenorhabditis elegans
NADPH oxidase
-
 Caenorhabditis elegans

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Caenorhabditis elegans
NADPH
-
 Caenorhabditis elegans

General Information

General Information Comment Organism
malfunction a lesion in BLI-3's NADPH oxidase domain increases sensitivity to pathogen and diminishes lifespan Caenorhabditis elegans
physiological function the enzyme BLI-3 has roles in both cuticle development and in protection against infection with Enterococcus faecalis Caenorhabditis elegans