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Literature summary for 1.6.3.5 extracted from

  • Sizova, D.; Velazquez, H.; Sampaio-Maia, B.; Quelhas-Santos, J.; Pestana, M.; Desir, G.V.
    Renalase regulates renal dopamine and phosphate metabolism (2013), Am. J. Physiol. Renal Physiol., 305, F839-F844.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine renalase deficiency is associated with increased renal dopamine synthesis, stimulated phosphate excretion, and moderately severe hypophosphatemia. The signal to increase renal dopamine synthesis is strong since it overcomes a compensatory increase in catechol-O-methyl transferase activity Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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General Information

General Information Comment Organism
physiological function renalase knockout mouse model to explore the mechanisms mediating renalase's effect on phosphate excretion. Compared with wild-type mice maintained on a regular diet, knockout mice show decreased serum phosphate and increased urinary phosphate excretion. Both wild-type and knocout mice respond similarly to phosphate restriction by increasing renal catechol-O-methyl transferase COMT-1 activity and markedly decreasing phosphate excretion. Only catechol-O-methyl transferase expression and activity are significantly increased in knockout mice. Urinary dopamine increases by twofold, whereas urinary l-DOPA excretion decreases by twofold in the knockout mouse Mus musculus