Any feedback?
Please rate this page

BRENDA support

Literature summary for extracted from

  • Wu, Y.; Quan, C.; Yang, Y.; Liang, Z.; Jiang, W.; Li, X.
    Renalase improves pressure overload-induced heart failure in rats by regulating extracellular signal-regulated protein kinase 1/2 signaling (2021), Hypertens. Res., 44, 481-488 .
    View publication on PubMed


Organism UniProt Comment Textmining
Rattus norvegicus Q5U2W9

Source Tissue

Source Tissue Comment Organism Textmining

General Information

General Information Comment Organism
physiological function during transverse aortic constriction-induced heart failure, renalase is directly associated with P38 and extracellular signal-regulated protein kinase 1/2 signaling. Renalase inhibition attenuates the noradrenaline-induced hypertrophic response in vitro or the pressure overload-induced hypertrophic response in vivo. Recombinant renalase protein significantly alleviates pressure overload-induced cardiac failure and is associated with P38 and ERK1/2 signaling Rattus norvegicus