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Literature summary for 1.6.3.5 extracted from

  • Catak, Z.; Kocdemir, E.; Ugur, K.; Yardim, M.; Sahin, I.; Kaya, H.; Aydin, S.
    A novel biomarker renalase and its relationship with its substrates in schizophrenia (2019), J. Med. Biochem., 38, 299-305 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine renalase levels are significantly lower in schizophrenia patients than in the control group, whereas dopamine levels are significantly higher. The epinephrine levels of both groups are similar, while the norepinephrine levels in patients with schizophrenia are significantly lower than those in the control group Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5VYX0
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General Information

General Information Comment Organism
drug target high dopamine levels in patients with schizophrenia might be due to low renalase levels. Renalase enzyme levels may play a substantial role in the pathophysiology of schizophrenia. Renalase levels are significantly lower in schizophrenia patients than in the control group, whereas dopamine levels are significantly higher. The epinephrine levels of both groups are similar, while the norepinephrine levels in patients with schizophrenia are significantly lower than those in the control group Homo sapiens