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Literature summary for 1.6.5.2 extracted from

  • Fasco, M.J.; Principe, L.M.
    Vitamin K1 hydroquinone formation catalyzed by DT-diaphorase (1982), Biochem. Biophys. Res. Commun., 104, 187-192.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3,3'-methylene-bis(4-hydroxycoumarin) competitive vs. NADH, uncompetitive vs. vitamin K1 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002
-
menadione
-
Rattus norvegicus
0.0175
-
NADH
-
Rattus norvegicus
0.0233
-
oxidized 2,6-dichlorophenolindophenol
-
Rattus norvegicus
0.0305
-
NADH in the presence of 0.026 mM dicoumarol Rattus norvegicus
0.0641
-
vitamin K1
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
quinone + NAD(P)H Rattus norvegicus protection of cells against damage by reactive oxygen species generated during oxidative cycling of quinones and semiquinone radicals hydroquinone + NAD(P)+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
3 to 4fold induction by 3-methylcholanthrene
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methyl-1,4-naphthoquinone + NAD(P)H artificial acceptor, trivial name menadione Rattus norvegicus 2-methyl-1,4-naphthoquinol + NAD(P)+
-
?
2-methyl-3-phytyl-1,4-naphthoquinone + NAD(P)H trivial name vitamin K1 Rattus norvegicus 2-methyl-3-phytyl-1,4-naphthohydroquinone + NAD(P)+
-
?
NAD(P)H + H+ + oxidized 2,6-dichlorophenolindophenol
-
Rattus norvegicus NAD(P)+ + reduced 2,6-dichlorophenolindophenol
-
?
oxidized 2,6-dichlorophenolindophenol + NADH + H+
-
Rattus norvegicus reduced 2,6-dichlorophenolindophenol + NAD+
-
r
quinone + NAD(P)H protection of cells against damage by reactive oxygen species generated during oxidative cycling of quinones and semiquinone radicals Rattus norvegicus hydroquinone + NAD(P)+
-
?

Cofactor

Cofactor Comment Organism Structure
FAD required Rattus norvegicus
NADH
-
Rattus norvegicus
NADPH
-
Rattus norvegicus