Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,3'-methylene-bis(4-hydroxycoumarin) | competitive vs. NADH, uncompetitive vs. vitamin K1 | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
menadione | - |
Rattus norvegicus | |
0.0175 | - |
NADH | - |
Rattus norvegicus | |
0.0233 | - |
oxidized 2,6-dichlorophenolindophenol | - |
Rattus norvegicus | |
0.0305 | - |
NADH | in the presence of 0.026 mM dicoumarol | Rattus norvegicus | |
0.0641 | - |
vitamin K1 | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
quinone + NAD(P)H | Rattus norvegicus | protection of cells against damage by reactive oxygen species generated during oxidative cycling of quinones and semiquinone radicals | hydroquinone + NAD(P)+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
3 to 4fold induction by 3-methylcholanthrene | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-methyl-1,4-naphthoquinone + NAD(P)H | artificial acceptor, trivial name menadione | Rattus norvegicus | 2-methyl-1,4-naphthoquinol + NAD(P)+ | - |
? | |
2-methyl-3-phytyl-1,4-naphthoquinone + NAD(P)H | trivial name vitamin K1 | Rattus norvegicus | 2-methyl-3-phytyl-1,4-naphthohydroquinone + NAD(P)+ | - |
? | |
NAD(P)H + H+ + oxidized 2,6-dichlorophenolindophenol | - |
Rattus norvegicus | NAD(P)+ + reduced 2,6-dichlorophenolindophenol | - |
? | |
oxidized 2,6-dichlorophenolindophenol + NADH + H+ | - |
Rattus norvegicus | reduced 2,6-dichlorophenolindophenol + NAD+ | - |
r | |
quinone + NAD(P)H | protection of cells against damage by reactive oxygen species generated during oxidative cycling of quinones and semiquinone radicals | Rattus norvegicus | hydroquinone + NAD(P)+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | required | Rattus norvegicus | |
NADH | - |
Rattus norvegicus | |
NADPH | - |
Rattus norvegicus |