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Literature summary for 1.6.5.2 extracted from

  • Chen, S.; Knox, R.; Lewis, A.D.; Friedlos, F.; Workman, P.; Deng, P.S.K.; Fung, M.; Ebenstein, D.; Wu, K.; Tsai, T.M.
    Catalytic properties of NAD(P)H:quinone acceptor oxidoreductase: study involving mouse, rat, human, and mouse-rat chimeric enzymes (1995), Mol. Pharmacol., 47, 934-939.
    View publication on PubMed
Search for more literature for 1.6.5.2

Application

Application Comment Organism
medicine activation of antitumor prodrugs Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus
-
 Homo sapiens
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
3,3'-methylene-bis(4-hydroxycoumarin)
-
 Homo sapiens
3,3'-methylene-bis(4-hydroxycoumarin)
-
 Mus musculus
3,3'-methylene-bis(4-hydroxycoumarin)
-
 Rattus norvegicus
5,7-dihydroxyflavone
-
 Homo sapiens
5,7-dihydroxyflavone
-
 Mus musculus
5,7-dihydroxyflavone
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.025
-
 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-dione
-
 Homo sapiens
0.027
-
 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-dione
-
 Rattus norvegicus
0.04
-
 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-dione
-
 Mus musculus
0.1
-
 NADH
-
 Homo sapiens
0.11
-
 NADH
-
 Rattus norvegicus
0.12
-
 NADH
-
 Mus musculus
0.84
-
 5-(aziridin-1-yl)-4-hydroxylamino-2-benzamide
-
 Rattus norvegicus
1.28
-
 5-(aziridin-1-yl)-4-hydroxylamino-2-benzamide
-
 Mus musculus
1.37
-
 5-(aziridin-1-yl)-4-hydroxylamino-2-benzamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Mus musculus
recombinant enzyme Homo sapiens
recombinant enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methyl-1,4-naphthoquinone + NAD(P)H
-
 Mus musculus 2-methyl-1,4-naphthoquinol + NAD(P)+
-
 ?
2-methyl-1,4-naphthoquinone + NAD(P)H
-
 Rattus norvegicus 2-methyl-1,4-naphthoquinol + NAD(P)+
-
 ?
2-methyl-1,4-naphthoquinone + NAD(P)H involved in the process of reductive activation of several cytotoxic antitumor quinones, such as mitomycins, anthracyclines and azaridinylbenzoquinones Homo sapiens 2-methyl-1,4-naphthoquinol + NAD(P)+
-
 ?
5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-dione + NAD(P)H
-
 Mus musculus 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-diol + NAD(P)+
-
 ?
5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-dione + NAD(P)H
-
 Homo sapiens 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-diol + NAD(P)+
-
 ?
5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-dione + NAD(P)H
-
 Rattus norvegicus 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-diol + NAD(P)+
-
 ?
5-(aziridin-1-yl)-2,4-dinitrobenzamide + NAD(P)H
-
 Mus musculus 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide + NAD(P)+
-
 ?
5-(aziridin-1-yl)-2,4-dinitrobenzamide + NAD(P)H
-
 Homo sapiens 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide + NAD(P)+
-
 ?
5-(aziridin-1-yl)-2,4-dinitrobenzamide + NAD(P)H
-
 Rattus norvegicus 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide + NAD(P)+
-
 ?
5-(aziridin-1-yl)-2,4-dinitrobenzamide + reduced dihydronicotineamide riboside
-
 Mus musculus 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide + oxidized dihydronicotineamide riboside
-
 ?
5-(aziridin-1-yl)-2,4-dinitrobenzamide + reduced dihydronicotineamide riboside
-
 Homo sapiens 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide + oxidized dihydronicotineamide riboside
-
 ?
5-(aziridin-1-yl)-2,4-dinitrobenzamide + reduced dihydronicotineamide riboside
-
 Rattus norvegicus 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide + oxidized dihydronicotineamide riboside
-
 ?
menadione + NADH + H+
-
 Mus musculus menadiol + NAD+
-
 r

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.07
-
 5,7-dihydroxyflavone
-
 Homo sapiens
0.08
-
 5,7-dihydroxyflavone
-
 Rattus norvegicus
0.68
-
 5,7-dihydroxyflavone
-
 Mus musculus