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Literature summary for 1.6.5.2 extracted from
- Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development (1999), Biochem. Pharmacol., 58, 303-310.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5,6-dimethylxanthenone-4-acetic acid | tumour blood flow inhibitor, competitive vs. NADH | Homo sapiens |  |
| flavone-8-acetic acid | tumour blood flow inhibitor, competitive vs. NADH | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 435.3 | - |
recombinant enzyme | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
5,6-dimethylxanthenone-4-acetic acid | - |
Homo sapiens | |
| 0.075 | - |
flavone-8-acetic acid | - |
Homo sapiens | |
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