Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | plays one of the main roles in the bioactivation of quinoidal drugs | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,4-benzoquinone + NADPH | - |
Rattus norvegicus | 1,4-benzosemiquinone + NADP+ | - |
? | |
1,4-naphthoquinone + NADPH + H+ | - |
Rattus norvegicus | 1,4-naphthoquinol + NADP+ | - |
? | |
1,8-dihydroxy-9,10-anthraquinone + NADPH | - |
Rattus norvegicus | 1,8-dihydroxy-9,10-anthraquinol + NADP+ | - |
? | |
1-hydroxy-9,10-anthraquinone + NADPH | - |
Rattus norvegicus | 1-hydroxy-9,10-anthraquinol + NADP+ | - |
? | |
2,3-diglutathionyl-1,4-naphthoquinone + NADPH | - |
Rattus norvegicus | 2,3-diglutathionyl-1,4-naphthoquinol + NADP+ | - |
? | |
2,5-diaziridinyl-1,4-benzoquinone + NADPH | - |
Rattus norvegicus | 2,5-diaziridinyl-1,4-benzoquinol + NADP+ | - |
? | |
2,5-dihydroxy-1,4-naphthoquinone + NADPH | - |
Rattus norvegicus | 2,5-dihydroxy-1,4-naphthoquinol + NADP+ | - |
? | |
2,5-dimethyl-1,4-benzoquinone + NADPH | - |
Rattus norvegicus | 2,5-dimethyl-1,4-benzoquinol + NADP+ | - |
? | |
2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone + NADPH | - |
Rattus norvegicus | 2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinol + NADP+ | - |
? | |
2,6-dimethyl-1,4-benzoquinone + NADPH | - |
Rattus norvegicus | 2,6-dimethyl-1,4-benzoquinol + NADP+ | - |
? | |
2-hydroxy-1,4-naphthoquinone + NADPH | - |
Rattus norvegicus | 2-hydroxy-1,4-naphthoquinol + NADP+ | - |
? | |
2-methyl-1,4-benzoquinone + NADPH | - |
Rattus norvegicus | 2-methyl-1,4-benzoquinol + NADP+ | - |
? | |
2-methyl-1,4-naphthoquinone + NADPH | - |
Rattus norvegicus | 2-methyl-1,4-naphthoquinol + NADp+ | - |
? | |
2-methyl-3-glutathionyl-5-hydroxy-1,4-naphthoquinone + NADPH | - |
Rattus norvegicus | 2-methyl-3-glutathionyl-5-hydroxy-1,4-naphthoquinol + NADP+ | - |
? | |
2-methyl-3-hydroxy-1,4-naphthoquinone + NADPH | - |
Rattus norvegicus | 2-methyl-3-hydroxy-1,4-naphthoquinol + NADP+ | - |
? | |
2-methyl-5-hydroxy-1,4-naphthoquinone + NADPH | - |
Rattus norvegicus | 2-methyl-5-hydroxy-1,4-naphthoquinol + NADP+ | - |
? | |
5,8-dihydroxy-1,4-naphthoquinone + NADPH | - |
Rattus norvegicus | 5,8-dihydroxy-1,4-naphthoquinol + NADP+ | - |
? | |
5-hydroxy-1,4-naphthoquinone + NADPH | - |
Rattus norvegicus | 5-hydroxy-1,4-naphthosemiquinone + NADP+ | - |
? | |
9,10-anthraquinone-2,6-disulfonate + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
9,10-anthraquinone-2-sulfonate + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
9,10-phenanthrene quinone + NADPH | - |
Rattus norvegicus | 9,10-phenanthrene quinol + NADP+ | - |
? | |
mitomycin C + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
additional information | plays one of the main roles in the bioactivation of quinoidal drugs | Rattus norvegicus | ? | - |
? | |
riboflavin + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
tetramethyl-1,4-benzoquinone + NADPH | - |
Rattus norvegicus | tetramethyl-1,4-benzoquinol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DT-diaphorase | - |
Rattus norvegicus |
NAD(P)H:quinone oxidoreductase | - |
Rattus norvegicus |
NQO1 | - |
Rattus norvegicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.3 | - |
9,10-anthraquinone-2,6-disulfonate | pH 7.0 | Rattus norvegicus | |
4.4 | - |
2,3-diglutathionyl-1,4-naphthoquinone | pH 7.0 | Rattus norvegicus | |
26.3 | - |
2-methyl-3-glutathionyl-5-hydroxy-1,4-naphthoquinone | pH 7.0 | Rattus norvegicus | |
52 | - |
9,10-phenanthrene quinone | pH 7.0 | Rattus norvegicus | |
71 | - |
5,8-Dihydroxy-1,4-naphthoquinone | pH 7.0 | Rattus norvegicus | |
222 | - |
2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone | pH 7.0 | Rattus norvegicus | |
242 | - |
5-hydroxy-1,4-naphthoquinone | pH 7.0 | Rattus norvegicus | |
287 | - |
2-methyl-1,4-benzoquinone | pH 7.0 | Rattus norvegicus | |
380 | - |
2-methyl-1,4-naphthoquinone | pH 7.0 | Rattus norvegicus | |
431 | - |
1,4-Naphthoquinone | pH 7.0 | Rattus norvegicus | |
500 | - |
2-methyl-5-hydroxy-1,4-naphthoquinone | pH 7.0 | Rattus norvegicus | |
500 | - |
2,5-dimethyl-1,4-benzoquinone | pH 7.0 | Rattus norvegicus | |
625 | - |
2,6-dimethyl-1,4-benzoquinone | pH 7.0 | Rattus norvegicus | |
769 | - |
1,4-benzoquinone | pH 7.0 | Rattus norvegicus | |
2331 | - |
2,5-diaziridinyl-1,4-benzoquinone | pH 7.0 | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |