Literature summary for 1.6.5.2 extracted from

Gustafson, D.L.; Siegel, D.; Rastatter, J.C.; Merz, A.L.; Parpal, J.C.; Kepa, J.K.; Ross, D.; Long, M.E.
Kinetics of NAD(P)H:quinone oxidoreductase I (NQO1) inhibition by mitomycin C in vitro and in vivo (2003), J. Pharmacol. Exp. Ther., 305, 1079-1086.

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Inhibitors

Inhibitors	Comment	Organism	Structure
5-methoxy-1,2-dimethyl-[(4-nitrophenoxy)methyl]indole-4,7-dione	-	Homo sapiens
5-methoxy-1,2-dimethyl-[(4-nitrophenoxy)methyl]indole-4,7-dione	-	Mus musculus
mitomycin C	mechanism-based inhibitor, in a pH-dependent manner	Homo sapiens
mitomycin C	mechanism-based inhibitor, in a pH-dependent manner	Mus musculus
mitomycin C	mechanism-based inhibitor, in a pH-dependent manner	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-
Rattus norvegicus	-	-	-

Synonyms

Synonyms	Comment	Organism
NAD(P)H:quinone oxidoreductase I	-	Mus musculus
NAD(P)H:quinone oxidoreductase I	-	Homo sapiens
NAD(P)H:quinone oxidoreductase I	-	Rattus norvegicus
NQO1	-	Mus musculus
NQO1	-	Homo sapiens
NQO1	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0254	-	mitomycin C	-	Rattus norvegicus
0.0648	-	mitomycin C	-	Homo sapiens
0.0832	-	mitomycin C	-	Mus musculus

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Release 2023.1 (January 2023)