Literature summary for 1.6.5.2 extracted from

Casalino, E.; Calzaretti, G.; Landriscina, M.; Sblano, C.; Fabiano, A.; Landriscina, C.
The Nrf2 transcription factor contributes to the induction of alpha-class GST isoenzymes in liver of acute cadmium or manganese intoxicated rats: comparison with the toxic effect on NAD(P)H:quinone reductase (2007), Toxicology, 237, 24-34.

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Application

Application	Comment	Organism
medicine	acute manganese intoxication, similarly to that of cadmium and other heavy metals, increases both the hepatic level of Nrf2 and its transfer from the cytoplasm to the nucleus where it actively regulates the induction of phase II enzymes, e.g. NQO1	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Cd2+	strongly stimulates NQO1 in the liver of intoxicated rats	Rattus norvegicus
Mn2+	strongly stimulates NQO1 in the liver of intoxicated rats	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male Wistar rats	-
Rattus norvegicus	-	male, Wistar	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.00022	-	48 h after after oral administration of vitamin E	Rattus norvegicus
0.00023	-	control, 24 h	Rattus norvegicus
0.00024	-	24 h after after oral administration of vitamin E	Rattus norvegicus
0.00024	-	48 h after oral administration of manganese	Rattus norvegicus
0.00024	-	control, 24 h	Rattus norvegicus
0.00025	-	48 h after oral administration of cadmium and vitamin E	Rattus norvegicus
0.00026	-	48 h after after oral administration of cadmium	Rattus norvegicus
0.00055	-	24 h after oral administration of manganese	Rattus norvegicus
0.00056	-	24 h after oral administration of cadmium and vitamin E	Rattus norvegicus
0.00059	-	24 h after after oral administration of cadmium	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
menadione + NADH	-	Rattus norvegicus	reduced menadione + NAD+	-	?
NADPH + H+ + quinone	TNF alpha and LPS induce Nqo1 mRNA expression	Rattus norvegicus	NADP+ + ?	-	?

Synonyms

Synonyms	Comment	Organism
NAD(P)H:quinone reductase	-	Rattus norvegicus
NADPH:quinone oxidoreductase 1	-	Rattus norvegicus
NQO1	-	Rattus norvegicus

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Release 2023.1 (January 2023)