Activating Compound | Comment | Organism | Structure |
---|---|---|---|
actinomycin D | treatment of the cells with actinomycin D alone for 6 h significantly inhibits the constitutive NQO1 mRNA level by approximately 80%. KTZ- and ITZ-mediated Nqo1 induction is completely inhibited | Mus musculus | |
itraconazole | induces NQO1 mRNA and enzymatic activity levels in a concentration- and time-dependent manner in wild-type but not aryl hydrocarbon receptor-deficient Hepa-1c1c7 cells. Increases NQO1 de novo RNA synthesis without significantly affecting the levels of existing RNA. 50 micromol shows maximum NQO1 mRNA induction | Mus musculus | |
ketoconazole | induces NQO1 mRNA and enzymatic activity levels in a concentration- and time-dependent manner in wild-type but not aryl hydrocarbon receptor-deficient Hepa-1c1c7 cells. Increases NQO1 de novo RNA synthesis without significantly affecting the levels of existing RNA. 25 micromol shows maximum NQO1 mRNA induction | Mus musculus | |
additional information | fluconazole does not induce NQO1 | Mus musculus | |
sulforaphane | at a concentration of 5 micromol significantly induces NQO1 mRNA in both wild-type and C12 cells | Mus musculus |
Application | Comment | Organism |
---|---|---|
drug development | ability of ketoconazole and itraconazole to induce NQO1 gene expression at the transcriptional level through an aryl hydrocarbon receptor-dependent mechanism | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hepa-1c1c7 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD(P)H + H+ + oxidized 2,6-dichlorophenolindophenol | - |
Mus musculus | NAD(P)+ + reduced 2,6-dichlorophenolindophenol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DT-diaphorase | - |
Mus musculus |
NAD(P)H:quinone oxidoreductase 1 | - |
Mus musculus |
NQO1 | - |
Mus musculus |