Literature summary for 1.6.5.2 extracted from

Munday, R.; Zhang, Y.; Munday, C.M.; Bapardekar, M.V.; Paonessa, J.D.
Structure-activity relationships and organ specificity in the induction of GST and NQO1 by alkyl-aryl isothiocyanates (2008), Pharm. Res., 25, 2164-2170.

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Activating Compound

Activating Compound	Comment	Organism	Structure
alpha-methylbenzyl isothiocyanate	in vivo, the organ most susceptible to the inductive activity of the isothiocyanates is the urinary bladder, with alpha-methylbenzyl isothiocyanate and cyclohexylmethyl isothiocyanate being the most effective. Inductive activity in the bladder in vivo does not correlate with that in bladder cells in vitro	Rattus norvegicus
cyclohexylmethyl isothiocyanate	in vivo, the organ most susceptible to the inductive activity of the isothiocyanates is the urinary bladder, with alpha-methylbenzyl isothiocyanate and cyclohexylmethyl isothiocyanate being the most effective. Inductive activity in the bladder in vivo does not correlate with that in bladder cells in vitro	Rattus norvegicus

Application

Application	Comment	Organism
drug development	induction of phase 2 enzymes, e.g. NQO1 increases resistance to chemical carcinogenesis. Isothiocyanates can therefore be valuable chemopreventative agents, and the specificity of these substances toward the urinary bladder suggest that they may be particularly useful for protecting against bladder cancer	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	female Sprague-Dawley rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
duodenum	-	Rattus norvegicus	-
forestomach	-	Rattus norvegicus	-
ileum	-	Rattus norvegicus	-
jejunum	-	Rattus norvegicus	-
small intestine	-	Rattus norvegicus	-
urinary bladder	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
menadione + NADH	-	Rattus norvegicus	reduced menadione + NAD+	-	?

Synonyms

Synonyms	Comment	Organism
NAD[P]H:quinone acceptor oxidoreductase 1	-	Rattus norvegicus
NQO1	-	Rattus norvegicus

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Release 2023.1 (January 2023)