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Literature summary for 1.6.5.2 extracted from

  • Lim, J.H.; Kim, K.M.; Kim, S.W.; Hwang, O.; Choi, H.J.
    Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: novel cytoprotective mechanism against oxidative damage (2008), Pharmacol. Res., 57, 325-331.
    View publication on PubMed
Search for more literature for 1.6.5.2

Activating Compound

Activating Compound Comment Organism Structure
bromocriptine significantly upregulates expression and activity (911% of untreated control) of NQO1, attenuates increase in protein-bound quinone in H2O2-treated PC12 cells, and protects PC12 cells against oxidative damage. Bromocriptine increases the expression and nuclear translocation of a basic leucine zipper transcription factor Nrf2, involved in the regulation of the enzyme Rattus norvegicus

Application

Application Comment Organism
drug development cytoprotective effect of bromocriptine involving PI3K- and Nrf2-mediated upregulation of the antioxidant enzyme NQO1, which may be a therapeutic strategy to protect cells from oxidative damage in Parkinson’s disease Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
dicoumarol in the presence of 0.050 mM of dicoumarol, the protective effect of bromocriptine against H2O2 is completely abolished Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-12 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD(P)H + H+ + oxidized 2,6-dichlorophenolindophenol
-
 Rattus norvegicus NAD(P)+ + reduced 2,6-dichlorophenolindophenol
-
 ?

Synonyms

Synonyms Comment Organism
EC 1.6.99.2 formerly Rattus norvegicus
NAD(P)H quinone oxidoreductase1
-
 Rattus norvegicus
NQO1
-
 Rattus norvegicus