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Literature summary for 1.6.5.9 extracted from
- Substrate-inducible versions of internal alternative NADH: ubiquinone oxidoreductase from Yarrowia lipolytica (2006), Yeast, 23, 1129-1136.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) pLysS cells | Yarrowia lipolytica |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme is rotenone-insensitive | Yarrowia lipolytica |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | alternative NADH dehydrogenase activity is located exclusively at the external face of the mitochondrial inner membrane | Yarrowia lipolytica | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55000 | - |
isoform NDH2i, SDS-PAGE | Yarrowia lipolytica |
| 60000 | - |
isoform NDH2e, SDS-PAGE | Yarrowia lipolytica |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Yarrowia lipolytica | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | NDH2 does not translocate protons across the inner mitochondrial membrane | Yarrowia lipolytica | ? | - |
? |  |
| NADH + H+ + n-decylubiquinone | - |
Yarrowia lipolytica | NAD+ + n-decylubiquinol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alternative NADH dehydrogenase | - |
Yarrowia lipolytica |
| external alternative NADH dehydrogenase | - |
Yarrowia lipolytica |
| external alternative NADH: ubiquinone oxidoreductase | - |
Yarrowia lipolytica |
| internal alternative NADH dehydrogenase | - |
Yarrowia lipolytica |
| internal alternative NADH: ubiquinone oxidoreductase | - |
Yarrowia lipolytica |
| NDH2e | isoform | Yarrowia lipolytica |
| NDH2i | isoform | Yarrowia lipolytica |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Yarrowia lipolytica | |
| NADH | - |
Yarrowia lipolytica | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | isoform NDH2i allows survival of double mutants lacking both complex I and isoform NDH2e | Yarrowia lipolytica |
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Release 2023.1 (January 2023)
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