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Literature summary for 1.6.5.9 extracted from

  • Dunn, E.A.; Cook, G.M.; Heikal, A.
    Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screening (2016), Data Brief, 6, 275-278 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol 20 microM, 149% of initial activity for detergent-solubilized enzyme Caldalkalibacillus thermarum
17-beta-hydroxy-17-alpha-ethynyl-delta-4-androstano[3,2-b]pyrimido[1,2-a]benzimidazole 20 microM, 142% of initial activity for detergent-solubilized enzyme Caldalkalibacillus thermarum
2,6-difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide 20 microM, 136% of initial activity for detergent-solubilized enzyme, 134% of initial activity for lipid-reconstituted enzyme Caldalkalibacillus thermarum
pentylenetetrazole 20 microM, 132% of initial activity for detergent-solubilized enzyme Caldalkalibacillus thermarum

Inhibitors

Inhibitors Comment Organism Structure
mangostin 20 microM, 19% residual activity for detergent-solubilized enzyme Caldalkalibacillus thermarum
morin 20 microM, 32% residual activity for detergent-solubilized enzyme, 18.7% residual activity for lipid-reconstituted enzyme Caldalkalibacillus thermarum
nordihydroguaiaretic acid 20 microM, 33% residual activity for detergent-solubilized enzyme, 18.7% residual activity for lipid-reconstituted enzyme Caldalkalibacillus thermarum
piceatannol 20 microM, 35% residual activity for detergent-solubilized enzyme Caldalkalibacillus thermarum
tyrphostin AG 537 20 microM, 22% residual activity for detergent-solubilized enzyme, 57% residual activity for lipid-reconstituted enzyme Caldalkalibacillus thermarum
tyrphostin AG 808 20 microM, 7% residual activity for detergent-solubilized enzyme Caldalkalibacillus thermarum

Organism

Organism UniProt Comment Textmining
Caldalkalibacillus thermarum F5L3B8
-
-
Caldalkalibacillus thermarum TA2.A1 F5L3B8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + H+ + menadione
-
Caldalkalibacillus thermarum NAD+ + menadiol
-
?
NADH + H+ + menadione
-
Caldalkalibacillus thermarum TA2.A1 NAD+ + menadiol
-
?