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Literature summary for 1.7.1.7 extracted from
- Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells (2003), J. Cancer Res. Clin. Oncol., 129, 76-83.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | potential target for the treatment of leukemia | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transfection of HL-60 leukemia cells, expressed in COS-7 cells as His-tag fusion protein | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 37800 | - |
calculated from the deduced amino acid sequence | Homo sapiens |
| 40000 | - |
His-tag fusion protein, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADPH + guanosine 5'-phosphate | Homo sapiens | important for the maintenance of the intracellular adenine guanine balance, possible role in the regulation of differentiation of leukemia cells | NADP+ + inosine 5'-phosphate + NH3 | - |
ir |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9P2T1 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| no glycoprotein | no glycosylation site found | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| from recombinant COS-7 cells | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | - |
Homo sapiens | - |
| G-361 cell | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| HeLa-S3 cell | - |
Homo sapiens | - |
| HL-60 cell | - |
Homo sapiens | - |
| K-562 cell | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| MOLT-4 cell | - |
Homo sapiens | - |
| monocyte | peripheral | Homo sapiens | - |
| ovary | - |
Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| prostate | - |
Homo sapiens | - |
| RAJI cell | - |
Homo sapiens | - |
| skeletal muscle | - |
Homo sapiens | - |
| small intestine | - |
Homo sapiens | - |
| spleen | - |
Homo sapiens | - |
| SW-480 cell | - |
Homo sapiens | - |
| testis | - |
Homo sapiens | - |
| thymus | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADPH + guanosine 5'-phosphate | - |
Homo sapiens | NADP+ + inosine 5'-phosphate + NH3 | - |
ir | |
| NADPH + guanosine 5'-phosphate | important for the maintenance of the intracellular adenine guanine balance, possible role in the regulation of differentiation of leukemia cells | Homo sapiens | NADP+ + inosine 5'-phosphate + NH3 | - |
ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GMPR2 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
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