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Literature summary for extracted from

  • Suzuki, K.
    Distribution of 4-nitroquinoline 1-oxide reductase in the mucosa of canine digestive tract (1978), Gann, 69, 229-235.
    View publication on PubMed


Localization Comment Organism GeneOntology No. Textmining
cytosol most of the activity Canis lupus familiaris 5829


Organism UniProt Comment Textmining
Canis lupus familiaris


Reaction Comment Organism Reaction ID
4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+ 4-(hydroxyamino)quinoline N-oxide may be the active intermediate essential in the carcinogenic process of 4-nitroquinoline N-oxide Canis lupus familiaris

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
activity in cytosol from mucous membrane of esophagus Canis lupus familiaris

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitroquinoline N-oxide + NAD(P)H + H+
Canis lupus familiaris 4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O