Literature summary for 1.7.2.4 extracted from

Ertem, M.Z.; Cramer, C.J.; Himo, F.; Siegbahn, P.E.
N-O bond cleavage mechanism(s) in nitrous oxide reductase (2012), J. Biol. Inorg. Chem., 17, 687-698.

Crystallization (Commentary)

Crystallization (Comment)	Organism
building of two models of the active site reveals two distinct mechanisms. In the first model, N2O binds to the fully reduced tetranuclear Cu4S core in a bent my-(1,3)-O,N bridging fashion between the CuI and CuIV centres and subsequently extrudes N2 while generating the corresponding bridged my-oxo species. In the second model, substrate N2O binds loosely to one of the coppers of the tetranuclear Cu4S core in a terminal fashion, i.e., using only the oxygen atom. Loss of N2 generates the same my-oxo copper core. The free energies of activation predicted for these two alternative pathways are close to one another and do not provide decisive support for one over the other	Paracoccus denitrificans

Crystallization (Comment)

Organism

building of two models of the active site reveals two distinct mechanisms. In the first model, N2O binds to the fully reduced tetranuclear Cu4S core in a bent my-(1,3)-O,N bridging fashion between the CuI and CuIV centres and subsequently extrudes N2 while generating the corresponding bridged my-oxo species. In the second model, substrate N2O binds loosely to one of the coppers of the tetranuclear Cu4S core in a terminal fashion, i.e., using only the oxygen atom. Loss of N2 generates the same my-oxo copper core. The free energies of activation predicted for these two alternative pathways are close to one another and do not provide decisive support for one over the other

Paracoccus denitrificans

Organism

Organism	UniProt	Comment	Textmining
Paracoccus denitrificans	Q51705	-	-

Synonyms

Synonyms	Comment	Organism
NosZ	-	Paracoccus denitrificans

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Release 2023.1 (January 2023)