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Literature summary for 1.7.2.8 extracted from

  • Kostera, J.; Youngblut, M.D.; Slosarczyk, J.M.; Pacheco, A.A.
    Kinetic and product distribution analysis of NO. reductase activity in Nitrosomonas europaea hydroxylamine oxidoreductase (2008), J. Biol. Inorg. Chem., 13, 1073-1083.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
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additional information kinetics, both reaction steps show first-order dependence on nitric oxide Nitrosomonas europaea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hydroxylamine + NH3 + cytochrome c-554 Nitrosomonas europaea the ammonia-oxidizing bacterium Nitrosomonas europaea normally catalyzes the four-electron oxidation of hydroxylamine to nitrite, which is the second step in ammonia-dependent respiration. In the presence of methyl viologen monocation radical, HAO can catalyze the reduction of nitric oxide to ammonia, reaction of by cytochrome c nitrite reductase , EC 1.7.2.2, overview NO2 + H2O + reduced cytochrome c-554
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Organism

Organism UniProt Comment Textmining
Nitrosomonas europaea
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Reaction

Reaction Comment Organism Reaction ID
hydroxylamine + NH3 + acceptor = N2 + H2O + reduced acceptor catalytic mechanism, overview Nitrosomonas europaea

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hydroxylamine + NH3 + cytochrome c-554
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Nitrosomonas europaea NO2 + H2O + reduced cytochrome c-554
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hydroxylamine + NH3 + cytochrome c-554 the ammonia-oxidizing bacterium Nitrosomonas europaea normally catalyzes the four-electron oxidation of hydroxylamine to nitrite, which is the second step in ammonia-dependent respiration. In the presence of methyl viologen monocation radical, HAO can catalyze the reduction of nitric oxide to ammonia, reaction of by cytochrome c nitrite reductase , EC 1.7.2.2, overview Nitrosomonas europaea NO2 + H2O + reduced cytochrome c-554
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additional information the enzyme catalyzes the four-electron oxidation of NH2OH to nitrite under aerobic conditions, HAO reacts with NO radical and NH2OH under reducing conditions Nitrosomonas europaea ?
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Subunits

Subunits Comment Organism
More arrangement of the eight hemes within one subunit of hydroxylamine oxidoreductase, structure, overview Nitrosomonas europaea

Synonyms

Synonyms Comment Organism
HAO
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Nitrosomonas europaea
hydroxylamine oxidoreductase
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Nitrosomonas europaea

Cofactor

Cofactor Comment Organism Structure
cytochrome c554 a soluble 26.1-kDa tetraheme protein that is quite abundant in the periplasm of Nitrosomas europaea and is the acceptor of the electrons from HAO in vivo Nitrosomonas europaea
cytochrome P460 heme-containing cofactor, overview Nitrosomonas europaea
heme several, structure and organization, overview Nitrosomonas europaea