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Literature summary for 1.7.3.3 extracted from

  • Bongaerts, G.P.A.; Uitzetter, J.; Brouns, R.; Vogels, G.D.
    Uricase of Bacillus fastidiosus. Properties and regulation of synthesis (1978), Biochim. Biophys. Acta, 527, 348-358.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,3,7-Trimethylxanthine i.e. caffeine, slight Metabacillus fastidiosus
3,7-Dimethylxanthine i.e. theobromine, slight Metabacillus fastidiosus
3-Methyluric acid
-
Metabacillus fastidiosus
5-Azaorotate
-
Metabacillus fastidiosus
7-Methyluric acid
-
Metabacillus fastidiosus
8-Azaxanthine
-
Metabacillus fastidiosus
9-methyluric acid
-
Metabacillus fastidiosus
Cd2+
-
Metabacillus fastidiosus
CN-
-
Metabacillus fastidiosus
Co2+
-
Metabacillus fastidiosus
Cr3+
-
Metabacillus fastidiosus
Cu2+
-
Metabacillus fastidiosus
Fe2+
-
Metabacillus fastidiosus
Hg2+ 1 mM: not Metabacillus fastidiosus
hypoxanthine
-
Metabacillus fastidiosus
Mg2+ 1 mM: not Metabacillus fastidiosus
Mn2+
-
Metabacillus fastidiosus
Ni2+
-
Metabacillus fastidiosus
Pb2+
-
Metabacillus fastidiosus
xanthine
-
Metabacillus fastidiosus
Zn2+
-
Metabacillus fastidiosus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell associated
-
Metabacillus fastidiosus
-
-
intracellular
-
Metabacillus fastidiosus 5622
-

Metals/Ions

Metals/Ions Comment Organism Structure
copper copper : uricase ratio is 1 : 7 Metabacillus fastidiosus
Iron iron : uricase ratio is 1 : 50 Metabacillus fastidiosus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
alpha2beta2, 2 * 36000 + 2 * 39000, SDS-PAGE Metabacillus fastidiosus
39000
-
alpha2beta2, 2 * 36000 + 2 * 39000, SDS-PAGE Metabacillus fastidiosus
145000 150000 gel filtration Metabacillus fastidiosus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
urate + O2 + H2O Metabacillus fastidiosus
-
5-hydroxyisourate + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Metabacillus fastidiosus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Metabacillus fastidiosus

Storage Stability

Storage Stability Organism
0-4°C, crystals in (NH4)2SO4 solution, 3 months, stable Metabacillus fastidiosus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
urate + O2 + H2O
-
Metabacillus fastidiosus 5-hydroxyisourate + H2O2
-
?

Subunits

Subunits Comment Organism
heterotetramer alpha2beta2, 2 * 36000 + 2 * 39000, SDS-PAGE Metabacillus fastidiosus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30 35
-
Metabacillus fastidiosus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
10 min, stable Metabacillus fastidiosus
60
-
10 min, 55% loss of activity Metabacillus fastidiosus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5
-
-
Metabacillus fastidiosus

pH Range

pH Minimum pH Maximum Comment Organism
8.5 10.5 50% of activity maximum at pH 8.5 and pH 10.5 Metabacillus fastidiosus

Cofactor

Cofactor Comment Organism Structure
additional information no cofactors Metabacillus fastidiosus