Crystallization (Comment) | Organism |
---|---|
enzyme in complex with substrate urate and inhibitor cyanide, X-ray diffraction structure determination and analysis | Aspergillus flavus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cyanide | - |
Aspergillus flavus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
urate + O2 + H2O | Aspergillus flavus | urate oxidase catalyzes the hydroxylation of uric acid into the metastable product 5-hydroxyisourate in the presence of molecular oxygen as part of the purine degradation pathway. 5-Hydroxyisourate decays slowly to allantoin, a process independent of oxygen and associated with the release of CO | 5-hydroxyisourate + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus flavus | Q00511 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
urate + O2 + H2O = 5-hydroxyisourate + H2O2 | catalytic mechanism, overview | Aspergillus flavus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
urate + O2 + H2O | urate oxidase catalyzes the hydroxylation of uric acid into the metastable product 5-hydroxyisourate in the presence of molecular oxygen as part of the purine degradation pathway. 5-Hydroxyisourate decays slowly to allantoin, a process independent of oxygen and associated with the release of CO | Aspergillus flavus | 5-hydroxyisourate + H2O2 | - |
? | |
urate + O2 + H2O | substrate binding involves residues Arg176 and Glu228, that hold the substrate, Phe159 closing one end of the cavity below, and the two residues Asn254 and Thr57, forming another tweezers above the mean plane of the ligand that construct a location where efficient electron transfer can take place at a low energy level via the catalytic triad Thr57, Lys10, and His256 | Aspergillus flavus | 5-hydroxyisourate + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Uox | - |
Aspergillus flavus |
uricase | - |
Aspergillus flavus |