Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.8.1.12 extracted from

  • Cunningham, M.L.; Zvelebil, M.J.J.M.; Fairlamb, A.H.
    Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals (1994), Eur. J. Biochem., 221, 285-295.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information activity is dependent on a redox-active cysteine at the active centre Crithidia fasciculata

General Stability

General Stability Organism
loss of 39% activity after incubation with NADPH at 25°C Crithidia fasciculata

Inhibitors

Inhibitors Comment Organism Structure
arsenite + NADPH, slightly Crithidia fasciculata
cymelarsen + NADPH Crithidia fasciculata
Melarsen oxide inhibition is increased in presence of NADPH, inhibition is abolished by melarsen-trypanothione disulfide adduct Crithidia fasciculata
melarsen-trypanothione disulfide adduct no inhibition Crithidia fasciculata
melarsoprol + NADPH, slightly Crithidia fasciculata
NADPH NADPH inhibits the enzyme at higher concentration and during longer incubation times, enzyme can be protected by NADP+ Crithidia fasciculata
phenylarsenoxide + NADPH Crithidia fasciculata

Organism

Organism UniProt Comment Textmining
Crithidia fasciculata
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Crithidia fasciculata

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
247
-
purified enzyme Crithidia fasciculata

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione disulfide + NADPH
-
Crithidia fasciculata trypanothione + NADP+
-
?

Synonyms

Synonyms Comment Organism
TR
-
Crithidia fasciculata

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
27
-
assay at Crithidia fasciculata

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
assay at Crithidia fasciculata

Cofactor

Cofactor Comment Organism Structure
FAD
-
Crithidia fasciculata
NADPH
-
Crithidia fasciculata

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.016
-
Melarsen oxide with melarsen-trypanothione disulfide-adduct Crithidia fasciculata
0.0172
-
Melarsen oxide with NADPH Crithidia fasciculata