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Literature summary for 1.8.1.12 extracted from

  • Ponasik, J.A.; Strickland, C.; Faerman, C.; Savvides, S.; Karplus, P.A.; Ganem, B.
    Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase (1995), Biochem. J., 311, 371-375.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
additional information activity is dependent on a redox-active cysteine at the active centre Crithidia fasciculata

Application

Application Comment Organism
medicine potential target for drug design against trypanosomiasis Crithidia fasciculata

Inhibitors

Inhibitors Comment Organism Structure
acylspermines and acylspermidines
-
Crithidia fasciculata
kukoamine A mixed inhibitor Crithidia fasciculata
N1N8-bis(dihydrocaffeoyl)spermidine
-
Crithidia fasciculata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trypanothione disulfide + NADPH Crithidia fasciculata protection against oxidative stress trypanothione + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Crithidia fasciculata
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione disulfide + NADPH
-
Crithidia fasciculata trypanothione + NADP+
-
?
trypanothione disulfide + NADPH protection against oxidative stress Crithidia fasciculata trypanothione + NADP+
-
?

Synonyms

Synonyms Comment Organism
TR
-
Crithidia fasciculata

Cofactor

Cofactor Comment Organism Structure
FAD
-
Crithidia fasciculata
NADPH
-
Crithidia fasciculata

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0018
-
kukoamine A
-
Crithidia fasciculata
0.0075
-
N1N8-bis(dihydrocaffeoyl)spermidine
-
Crithidia fasciculata
0.011 0.607 acylspermines and acylspermidines
-
Crithidia fasciculata