Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activity is dependent on a redox-active cysteine at the active centre | Crithidia fasciculata |
Application | Comment | Organism |
---|---|---|
medicine | potential target for drug design against trypanosomiasis | Crithidia fasciculata |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acylspermines and acylspermidines | - |
Crithidia fasciculata | |
kukoamine A | mixed inhibitor | Crithidia fasciculata | |
N1N8-bis(dihydrocaffeoyl)spermidine | - |
Crithidia fasciculata |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | Crithidia fasciculata | protection against oxidative stress | trypanothione + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crithidia fasciculata | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | - |
Crithidia fasciculata | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH | protection against oxidative stress | Crithidia fasciculata | trypanothione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TR | - |
Crithidia fasciculata |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Crithidia fasciculata | |
NADPH | - |
Crithidia fasciculata |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0018 | - |
kukoamine A | - |
Crithidia fasciculata | |
0.0075 | - |
N1N8-bis(dihydrocaffeoyl)spermidine | - |
Crithidia fasciculata | |
0.011 | 0.607 | acylspermines and acylspermidines | - |
Crithidia fasciculata |