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Literature summary for 1.8.1.12 extracted from

  • Stump, B.; Eberle, C.; Schweizer, W.; Kaiser, M.; Brun, R.; Krauth-Siegel, R.; Lentz, D.; Diederich, F.
    Pentafluorosulfanyl as a novel building block for enzyme inhibitors: Trypanothione reductase inhibition and antiprotozoal activities of diarylamines (2009), ChemBioChem, 10, 79-83.
    View publication on PubMed
Search for more literature for 1.8.1.12

Inhibitors

Inhibitors Comment Organism Structure
3-([2-[(4-tert-butylphenyl)amino]-5-fluorophenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride mixed-type inhibition Trypanosoma cruzi
N-(3,4-dichlorobenzyl)-3-[(5-fluoro-2-[[4-(pentafluoro-l6-sulfanyl)phenyl]amino]phenyl)amino]-N,N-dimethylpropan-1-aminium chloride mixed-type inhibition Trypanosoma cruzi
N-(3,4-dichlorobenzyl)-3-[(5-fluoro-2-[[4-(trifluoromethyl)phenyl]amino]phenyl)amino]-N,N-dimethylpropan-1-aminium chloride competitive inhibition Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi P28593
-
-

Synonyms

Synonyms Comment Organism
EC 1.6.4.8 formerly Trypanosoma cruzi
trypanothione reductase
-
 Trypanosoma cruzi

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Trypanosoma cruzi

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.028
-
 N-(3,4-dichlorobenzyl)-3-[(5-fluoro-2-[[4-(pentafluoro-l6-sulfanyl)phenyl]amino]phenyl)amino]-N,N-dimethylpropan-1-aminium chloride competitive inhibition, at 25°C Trypanosoma cruzi
0.084
-
 3-([2-[(4-tert-butylphenyl)amino]-5-fluorophenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride competitive inhibition, at 25°C Trypanosoma cruzi
0.158
-
 3-([2-[(4-tert-butylphenyl)amino]-5-fluorophenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride uncompetitive inhibition, at 25°C Trypanosoma cruzi
0.72
-
 N-(3,4-dichlorobenzyl)-3-[(5-fluoro-2-[[4-(pentafluoro-l6-sulfanyl)phenyl]amino]phenyl)amino]-N,N-dimethylpropan-1-aminium chloride uncompetitive inhibition, at 25°C Trypanosoma cruzi