Literature summary for 1.8.1.12 extracted from

Beig, M.; Oellien, F.; Garoff, L.; Noack, S.; Krauth-Siegel, R.L.; Selzer, P.M.
Trypanothione reductase a target protein for a combined in vitro and in silico screening approach (2015), PLoS Negl. Trop. Dis., 9, e0003773 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-[(7-chloro-4-nitro-2,1,3-benzothiadiazol-5-yl)sulfanyl]quinazoline	reversible. Compound inhibits parasite proliferation with EC50 values between 50 and 5 microM	Trypanosoma brucei brucei
5,7-dichloro-4-nitro-2,1,3-benzothiadiazole	reversible. Compound inhibits parasite proliferation with EC50 values between 50 and 5 microM	Trypanosoma brucei brucei
[[(7-nitro-2,1,3-benzoxadiazol-4-yl)methyl]sulfanyl]methyl phenylcarbamate	reversible. Compound inhibits parasite proliferation with EC50 values between 50 and 5 microM	Trypanosoma brucei brucei

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma brucei brucei	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00027	-	pH 7.5, 22°C	Trypanosoma brucei brucei	[[(7-nitro-2,1,3-benzoxadiazol-4-yl)methyl]sulfanyl]methyl phenylcarbamate
0.00058	-	pH 7.5, 22°C	Trypanosoma brucei brucei	4-[(7-chloro-4-nitro-2,1,3-benzothiadiazol-5-yl)sulfanyl]quinazoline
0.00061	-	pH 7.5, 22°C	Trypanosoma brucei brucei	5,7-dichloro-4-nitro-2,1,3-benzothiadiazole

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Release 2023.1 (January 2023)