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Literature summary for 1.8.1.12 extracted from
- Molecular insights into trypanothione reductase-inhibitor interaction A structure-based review (2018), Arch. Pharm., 351, e1700373 .
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structure of thr enzyme (LiTR) at 3.6 A resolution in its reduced state (complex with trypanothione) and oxidized state | Leishmania infantum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-(1-(benzo(b)thien-2-yl)cyclohexyl)piperidine | - |
Leishmania infantum | |
| 5-(5-(1-(pyrrolidin-1-yl)cyclohexyl)-1,3-thiazol-2-yl)-1H-indole | competitive inhibition | Leishmania infantum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trypanothione disulfide + NADPH + H+ | Leishmania infantum | - |
trypanothione + NADP+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania infantum | A4HSF7 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trypanothione disulfide + NADPH + H+ | - |
Leishmania infantum | trypanothione + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LiTR | - |
Leishmania infantum |
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Release 2023.1 (January 2023)
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