Literature summary for 1.8.1.12 extracted from

Vazquez, K.; Paulino, M.; Salas, C.O.; Zarate-Ramos, J.J.; Vera, B.; Rivera, G.
Trypanothione reductase a target for the development of anti-Trypanosoma cruzi drugs (2017), Mini Rev. Med. Chem., 17, 939-946 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
benzimidazole	-	Trypanosoma cruzi
chlorpromazine	-	Trypanosoma cruzi
cis-3-oxo-8,9b-bis-(trans-N1-(acrylamidospermidyl))-1,2,3,4,4a,9b-hexahydrodibenzofuran	-	Trypanosoma cruzi
clomipramine	-	Trypanosoma cruzi
indrataline	-	Trypanosoma cruzi
lunarine	-	Trypanosoma cruzi
N1,N4-bis(3-aminopropyl)-N1-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-10-yl)-N4-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)butane-1,4-diamine	-	Trypanosoma cruzi
N1-(3-aminopropyl)-N1-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-10-yl)butane-1,4-diamine	-	Trypanosoma cruzi
N1-(3-aminopropyl)-N1-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-10-yl)propane-1,3-diamine	-	Trypanosoma cruzi
prochlorperazine	-	Trypanosoma cruzi
Quinazoline	-	Trypanosoma cruzi
thioridazine	potent irreversible inhibitor. 100% inhibition at 0.010 mM	Trypanosoma cruzi
triflupromizine	-	Trypanosoma cruzi

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma cruzi	P28593	-	-

Synonyms

Synonyms	Comment	Organism
trypanothione reductase	-	Trypanosoma cruzi

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0065	-	clomipramine	pH and temperature not specified in the publication	Trypanosoma cruzi

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0038	-	pH and temperature not specified in the publication	Trypanosoma cruzi	clomipramine
0.0063	-	pH and temperature not specified in the publication	Trypanosoma cruzi	chlorpromazine
0.0074	-	pH and temperature not specified in the publication	Trypanosoma cruzi	prochlorperazine
0.0075	-	pH and temperature not specified in the publication	Trypanosoma cruzi	triflupromizine

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Release 2023.1 (January 2023)