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Literature summary for 1.8.1.12 extracted from

  • Maamri, S.; Benarous, K.; Yousfi, M.
    Identification of 3-methoxycarpachromene and masticadienonic acid as new target inhibitors against trypanothione reductase from Leishmania infantum using molecular docking and ADMET prediction (2021), Molecules, 26, 3335 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
3-methoxycarpachromene the potent biomolecule could be an effective strategy to solve antimony-resistant strains and represent a drug candidate as an anti-Trypanosomatidae species drug Leishmania infantum
masticadienonic acid the potent biomolecule could be an effective strategy to solve antimony-resistant strains and represent a drug candidate as an anti-Trypanosomatidae species drug Leishmania infantum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trypanothione disulfide + NADPH + H+ Leishmania infantum
-
trypanothione + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Leishmania infantum A4HSF7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione disulfide + NADPH + H+
-
Leishmania infantum trypanothione + NADP+
-
?

Synonyms

Synonyms Comment Organism
trypanothione reductase
-
Leishmania infantum

General Information

General Information Comment Organism
drug target the potent biomolecules 3-methoxycarpachromene and masticadienonic acid could be an effective strategy to solve antimony-resistant strains and represent drug candidates as anti-Trypanosomatidae species drugs Leishmania infantum