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Literature summary for 1.8.1.12 extracted from

  • Coro-Bermello, J.; Lopez-Rodriguez, E.; Alfonso-Ramos, J.; Alonso, D.; Ojeda-Carralero, G.; Prado, G.; Moreno-Castillo, E.
    Identification of novel thiadiazin derivatives as potentially selective inhibitors towards trypanothione reductase from Trypanosoma cruzi by molecular docking using the numerical index poses ratio Pr and the binding mode analysis (2021), SN Appl. Sci., 3, 376 .
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
additional information a virtual screening of a library of thiadiazine derivatives against trypanothione reductase using molecular docking is performed. Thiadiazine-based compounds are identified as plausible candidates to selectively inhibit the parasitic enzyme Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi P28593
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Synonyms

Synonyms Comment Organism
trypanothione reductase
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Trypanosoma cruzi

General Information

General Information Comment Organism
physiological function the enzyme plays a central role in the metabolic pathway of the parasite Trypanosoma cruzi