Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CoA-disulfide + NADH + H+ | Borreliella burgdorferi | - |
CoA + NAD+ | - |
? | |
CoA-disulfide + NADH + H+ | Borreliella burgdorferi B31 | - |
CoA + NAD+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Borreliella burgdorferi | - |
- |
- |
Borreliella burgdorferi B31 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CoA-disulfide + NADH + H+ | - |
Borreliella burgdorferi | CoA + NAD+ | - |
? | |
CoA-disulfide + NADH + H+ | - |
Borreliella burgdorferi B31 | CoA + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CoADR | - |
Borreliella burgdorferi |
coenzyme A disulphide reductase | - |
Borreliella burgdorferi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
coenzyme A | - |
Borreliella burgdorferi | |
NADH | - |
Borreliella burgdorferi |
General Information | Comment | Organism |
---|---|---|
malfunction | spirochetes lacking CoADR exhibit a growth defect under both aerobic and anaerobic conditions. Enzyme loss affects survival of spirochete in fed, but not flat tick nymphs | Borreliella burgdorferi |
physiological function | the enzyme of Borrelia burgdorferi is necessary to maintain optimal redox ratios for CoA/CoA-disulfide and NAD+/NADH during periods of rapid replication throughout the enzootic cycle, to support thiol-disulfide homeostasis, and to indirectly protect the spirochete against peroxide-mediated membrane damage. The enzyme is also required for infectivity in mice | Borreliella burgdorferi |