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Literature summary for 1.8.1.15 extracted from

  • Oosthuizen, C.; Gasa, N.; Hamilton, C.; Lall, N.
    Inhibition of mycothione disulphide reductase and mycobacterial biofilm by selected South African plants (2019), South Afr. J. Bot., 120, 291-297 .
No PubMed abstract available
Search for more literature for 1.8.1.15

Inhibitors

Inhibitors Comment Organism Structure
additional information plant extracts from Alectra sessiliflora, Aloe plicatilis, Eucomis humilis, Eucomis vandermerwei, Euphorbia tirrucalli, Faurea saligna, Merwillia plumbea, Salvia africana-lutea, Sphedamnocarpus pruriens, Tarchonanthus camphorates, Typha capensis, Typha minima, and Withania somnifera show inhibitory activities against the enzyme exhibiting IC50 values of 0.1678, 0.9934, 0.3206, 0.1347, 0.2391, 0.042, 0.2361, 0.1023, 0.0615, 0.1329, 0.0538, 0.0479, and 0.1624 mg/ml, respectively Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
mycothione + NADPH + H+ Mycobacterium tuberculosis
-
 2 mycothiol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mycothione + NADPH + H+
-
 Mycobacterium tuberculosis 2 mycothiol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
MTR
-
 Mycobacterium tuberculosis
mycothione disulphide reductase
-
 Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mycobacterium tuberculosis