Application | Comment | Organism |
---|---|---|
medicine | direct involvement of LpdC in the prolonged retention of coronin-1 on the phagosome, thus promoting phagosome maturation arrest. Under the influence of IFNgamma, LRG-47 is recruited to the phagosome and mediates dislocation of coronin-1 leading ultimately to phagosome acidification and recruitment of lysosomal vacuoles and phagolyosome fusion | Mycobacterium tuberculosis |
medicine | direct involvement of LpdC in the prolonged retention of coronin-1 on the phagosome, thus promoting phagosome maturation arrest. Under the influence of IFNgamma, LRG-47 is recruited to the phagosome and mediates dislocation of coronin-1 leading ultimately to phagosome acidification and recruitment of lysosomal vacuoles and phagolyosome fusion | Mycobacterium tuberculosis variant bovis BCG |
Cloned (Comment) | Organism |
---|---|
Mycobacterium smegmatis over-expressing LpdC protein | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | expression of LRG-47, as well as IFNgamma stimulation, block intracellular interaction of coronin-1 with LpdC | Mycobacterium tuberculosis | |
additional information | expression of LRG-47, as well as IFNgamma stimulation, block intracellular interaction of coronin-1 with LpdC | Mycobacterium tuberculosis variant bovis BCG |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
x * 50000, SDS-PAGE | Mycobacterium tuberculosis |
50000 | - |
? * 50000, SDS-PAGE | Mycobacterium tuberculosis variant bovis BCG |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Mycobacterium tuberculosis variant bovis BCG | - |
- |
- |
no activity in Mycobacterium smegmatis | - |
- |
- |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, SDS-PAGE | Mycobacterium tuberculosis |
? | ? * 50000, SDS-PAGE | Mycobacterium tuberculosis variant bovis BCG |
Synonyms | Comment | Organism |
---|---|---|
CIP50 | - |
Mycobacterium tuberculosis |
CIP50 | - |
Mycobacterium tuberculosis variant bovis BCG |
coronin-interacting protein | - |
Mycobacterium tuberculosis |
coronin-interacting protein | - |
Mycobacterium tuberculosis variant bovis BCG |
E3 | - |
Mycobacterium tuberculosis |
lipoamide dehydrogenase C | - |
Mycobacterium tuberculosis |
lipoamide dehydrogenase C | - |
Mycobacterium tuberculosis variant bovis BCG |
LpdC | - |
Mycobacterium tuberculosis |
LpdC | - |
Mycobacterium tuberculosis variant bovis BCG |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
5.4 |
Mycobacterium tuberculosis variant bovis BCG | - |
- |
5.4 |