Literature summary for 1.8.1.4 extracted from

Dhanasekaran, M.; Albano, C.B.; Pellet, L.; Karuppagounder, S.S.; Uthayathas, S.; Suppiramaniam, V.; Brown-Borg, H.; Ebadi, M.
Role of lipoamide dehydrogenase and metallothionein on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity (2008), Neurochem. Res., 33, 980-984.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Zn2+	dose dependently enhances the lipoamide dehydrogenase activity	Mus musculus

Application

Application	Comment	Organism
medicine	lipoamide dehydrogenase activity and metallothionein levels may be critical for dopaminergic neuronal survival in Parkinson's disease. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine can affect the lipoamide dehydrogenase activity and metallothionein content to exert its neurotoxicity	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	at higher concentrations (2 mM) significantly inhibits the lipoamide dehydrogenase activity	Mus musculus
1-methyl-4-phenylpyridinium	at lower concentrations (1 mM) as compared to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine significantly inhibits the lipoamide dehydrogenase activity	Mus musculus
Fe2+	at high concentrations has significant inhibitory effect on the lipoamide dehydrogenase activity	Mus musculus
additional information	calcium and copper do not affect the enzyme activity	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	C57/Bl-6 mice	-
Mus musculus C57/Bl-6	-	C57/Bl-6 mice	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
coenzyme Q-10 + NADPH	-	Mus musculus	ubiquinol + NADP+	-	?
coenzyme Q-10 + NADPH	-	Mus musculus C57/Bl-6	ubiquinol + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
lipoamide dehydrogenase	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Mus musculus

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Release 2023.1 (January 2023)